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KMID : 0369819950250010047
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 1 p.47 ~ p.54
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Skin Permeation Characteristics of Estradiol Patches and Their Comparative Efficacy Test in Ovariectomized Rabbits
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류제필. 최미숙. 최종근. 김수헌. 김응구. 윤병일
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Abstract
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Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the
unterotropic
effect on the ovariectomized rabbits. The design of patch of enhancers, amount of drug loading and coating coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation
profiles (following zero-kinetics), but the skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in
atrophy
of
the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).
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KEYWORD
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